陈国颂
博士
Email: guosong@fudan.edu.cn
电话: +86-21-31244275
课题组主页:
1997-2001 南开大学,化学学士
2001-2006 南开大学,物理化学博士
2006-2008 美国爱荷华州立大学化学系,有机化学博士后
2009-2011 复旦大学,讲师
2011-2014 复旦大学,副教授
2014 至今 复旦大学,教授、博士生导师
糖-蛋白相互作用诱导的蛋白质自组装
含糖组装体的免疫学功能
糖化学驱动的大分子组装
Yufei Zhang, Libin Wu, Zhen Li, Weiyi Zhang, Feifei Luo, Yiwei Chu, Guosong Chen*, “Glycocalyx-Mimicking Nanoparticles Improve Anti-PD-L1 Cancer Immunotherapy through Reversion of Tumor-Associated Macrophages” Biomacromolecules 2018, 19, x.
Libin Wu, Yufei Zhang, Zhen Li, Guang Yang, Zdravko Kochovski, Guosong Chen*, Ming Jiang, “"Sweet" Architecture-Dependent Uptake of Glycocalyx-Mimicking Nanoparticles Based on Biodegradable Aliphatic Polyesters by Macrophages” J. Am. Chem. Soc., 2017, 139, 14684-14692.
Wei Zheng, Guang Yang, Nannan Shao, Li-Jun Chen, Bo Ou, Shu-Ting Jiang, Guosong Chen*, Haibo Yang*, “CO2 Stimuli-Responsive, Injectable Block Copolymer Hydrogels Cross-linked by Discrete Organoplatinum(II) Metallacycles via Stepwise Post-Assembly Polymerization”, J. Am. Chem. Soc., 2017, 139, 13811-13820.
Guang Yang, Hong-ming Ding, Zdravko Kochovski, Rongting Hu, Yan Lu, Yu-qiang Ma*, Guosong Chen*, Ming Jiang “Highly ordered self-assembly of native proteins into 1D, 2D and 3D structures modulated by a tether length of inducing ligands”, Angew. Chem. Int. Ed. 2017, 56, 10691-10695.
Yu Zhao, Yufei Zhang, Changchun Wang, Guosong Chen*, Ming Jiang, “Role of Protecting Groups in Synthesis and Self-Assembly of Glycopolymers”, Biomacromolecules 2017, 18, 568-575.
Zhen Li, Liang Sun, Yufei Zhang, Andrew P Dove, Rachel K. O'Reilly*, Guosong Chen*, “Shape Effect of Glyco-Nanoparticles on Macrophage Uptake and Immune Response”, ACS Macro Lett., 2016, 5, 1059-0164.
Yijiang Liu, Yufei Zhang, Zheyu Wang, Jue Wang, Kongchang Wei, Guosong Chen*, Ming Jiang, “Building Nanowires from Micelles: Hierarchical Self-assembly of Alternating Amphiphilic Glycopolypeptide Brushes with Pendants of High-Mannose Glycodendron and Oligophenylalanine”, J. Am Chem. Soc. 2016, 138, 12387-12394.
Guang Yang, Libin Wu, Guosong Chen*, Ming Jiang, “Precise Protein Assembly to Array Structures”, Chem. Commun. 2016, 52, 10595-10605.
Zhongwei Ji, Junfang Li, Guosong Chen*, Ming Jiang, “Fate of Host-Stabilized Charge Transfer Complexation Based on Cucurbit[8]uril: Inducing Cyclization of PNIPAM and Dissociation in Self-Assembly of the Cyclic Polymer”, ACS Macro Lett. 2016, 5, 588-592.
Wei Zheng, Li-Jun Chen, Guang Yang, Bin Sun, Xu Wang, Bo Jiang, Guang-Qiang Yin, Li Zhang, Xiaopeng Li, Minghua Liu, Guosong Chen*, Haibo Yang*, “Construction of Smart Supramolecular Polymeric Hydrogels Cross-linked by Discrete Organoplatinum(II) Metallacycles via Post-Assembly Polymerization”, J. Am. Chem. Soc., 2016, 138, 4927-4937.
Guang Yang, Xiang Zhang, Zdravko Kochovski, Yufei Zhang, Bin Dai, Fuji Sakai, Lin Jiang, Yan Lu, Matthias Ballauff, Xueming Li, Cong Liu*, Guosong Chen*, Ming Jiang, “Precise and Reversible Protein-Microtubule-Like Structure with Helicity Driven by Dual Supramolecular Interactions”, J. Am. Chem. Soc., 2016, 138, 1932-1937.
Yijiang Liu, Yu Kang, Jue Wang, Zheyu Wang, Guosong Chen*, Ming Jiang, “Sequence-defined peptidocopolymers: the effect of small molecular linkers”, Biomacromolecules 2015, 16, 3995-4003.
Mingchang Lin, Yufei Zhang, Guosong Chen*, Ming Jiang, “Supramolecular glyco-nanoparticles toward immunological applications”, Small 2015, 11, 6065-6070.
Xiulong Wu, Lu Su, Guosong Chen*, Ming Jiang, “Deprotection-induced micellization of glycopolymers: control of kinetics and morphologies”, Macromolecules 2015, 48, 3705-3712.
Lu Su, Weiyi Zhang, Xiulong, Wu, Yufei Zhang, Xi Chen, Guangwei Liu, Guosong Chen*, Ming Jiang, “Glycocalyx-mimicking nanoparticles for stimulation and polarization of macrophages via specific interactions”, Small 2015, 11, 4191-4200.
Fuji Sakai, Guang Yang, Manfred S. Weiss, Yijiang Liu, Guosong Chen*, Ming Jiang*, “Protein Crystalline Frameworks with Controllable Interpenetration Directed by Dual Supramolecular Interactions” Nature Communications 2014, 5, 4634-9782.
Yu Zhao, Fuji Sakai, Lu Su, Yijiang Liu, Kongchang Wei, Guosong Chen*, Ming Jiang*, “Progressive Macromolecular Self-assembly: from Biomimetic Chemistry to Bio-inspired Materials” Adv. Mater. 2013, 25, 5215–5256.
Mingchang Lin, Guosong Chen*, Ming Jiang, “Glyco-stereoisomerism effect on hydrogelation of interacting polymers via dynamic covalent bond” Chem. Commun. 2014, 50, 9779-9782.
Kongchang Wei, Jun Li, Guosong Chen*, Ming Jiang, “Dual molecular recognition leading to a protein-polymer conjugate and further self-assembly” ACS Macro Lett. 2013, 2, 278-283.
2018 ACS PMSE Young Investigator Award
冯新德高分子奖(Elsevier杂志社)
第十八届诺贝尔奖获得者大会参加奖(国家自然科学基金委和德国DFG联合选拔)
Participation award of 18th Meeting of Nobel Price Winners in Chemistry at Lindau, Lake of Constance, Germany, 2006.
Associate Editor of ACS Macro Letters
Fellow of Royal Society of Chemitry (FRSC)
中国化学会第30届高分子学科委员会委员
《中国科学化学》青年编委